Positive serology for Helicobacter pylori and vomiting in the pregnancy

Haim Shirin*, Oscar Sadan, Orit Shevah, Rafael Bruck, Mona Boaz, Steven F. Moss, Samuel Everon, Marek Glezerman, Yona Avni

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Introduction: Recently, several investigators have suggested that H. pylori may be a contributory factor in hyperemesis gravidarum. The purpose of this study was to evaluate whether seropositivity for IgG antibodies to H. pylori may also be related to nausea, vomiting, heartburn and epigastric pain in pregnancy. Materials and methods: One hundred and eighty-five women, at term pregnancy, were included in the study. All women completed a questionnaire regarding information on the number of pregnancies and deliveries, weight gain, smoking and gastrointestinal complaints before and during pregnancy. The presence of H. pylori infection was determined by serology. Results: The overall prevalence rate of H. pylori seropositivity was 45.9%. Women positive for H. pylori IgG were older (28.7±4.5 vs. 27.0±4.5, p=0.02), had more prior pregnancies (3.2±2.1 vs. 2.6±1.6, p=0.02) and deliveries (2.6±1.6 vs. 2.0±1.1, p=0.006) and reported vomiting in the first trimester more frequently than H. pylori negative patients (81.2% vs. 65%, p=0.004). On the other hand vomiting in the second trimester was reported more frequently among smokers during pregnancy compared to non-smokers. Conclusions: H. pylori seropositivity is significantly associated with emesis gravidarum but not with gastro-intestinal symptoms later in pregnancy. First trimester vomiting more than doubles the likelihood that the gravida is H. pylori IgG positive.

Original languageEnglish
Pages (from-to)10-14
Number of pages5
JournalArchives of Gynecology and Obstetrics
Issue number1
StatePublished - Jul 2004


  • Heartburn
  • Helicobacter pylori
  • Pregnancy
  • Vomiting


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