@article{e552c34a7e404d8096aceea716432d97,
title = "Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: Cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure",
abstract = "Despite improvements in modern cardiovascular therapy, the morbidity and mortality of ischaemic heart disease (IHD) and heart failure (HF) remain significant in Europe and worldwide. Patients with IHD may benefit from therapies that would accelerate natural processes of postnatal collateral vessel formation and/or muscle regeneration. Here, we discuss the use of cells in the context of heart repair, and the most relevant results and current limitations from clinical trials using cell-based therapies to treat IHD and HF. We identify and discuss promising potential new therapeutic strategies that include ex vivo cell-mediated gene therapy, the use of biomaterials and cell-free therapies aimed at increasing the success rates of therapy for IHD and HF. The overall aim of this Position Paper of the ESC Working Group Cellular Biology of the Heart is to provide recommendations on how to improve the therapeutic application of cell-based therapies for cardiac regeneration and repair.",
keywords = "Cell-based therapy, Heart Failure, Heart Regeneration, Heart repair, Ischaemic heart disease",
author = "Rosalinda Madonna and {Van Laake}, {Linda W.} and Davidson, {Sean M.} and Engel, {Felix B.} and Hausenloy, {Derek J.} and Sandrine Lecour and Jonathan Leor and Cinzia Perrino and Rainer Schulz and Kirsti Ytrehus and Ulf Landmesser and Mummery, {Christine L.} and Stefan Janssens and James Willerson and Thomas Eschenhagen and Pter Ferdinandy and Sluijter, {Joost P.G.}",
note = "Publisher Copyright: {\textcopyright} The Author 2016.",
year = "2016",
month = jun,
day = "14",
doi = "10.1093/eurheartj/ehw113",
language = "אנגלית",
volume = "37",
pages = "1789--1798",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "23",
}
