Position and direction of strand exchange in bacteriophage HK022 integration

Mikhail Kolot*, Ezra Yagil

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The positions of the endonucleolytic cleavages promoted by the integrase protein (Int) of coliphage HK022 within its attB site were determined. The protein catalyses a staggered cut, which defines an overlap sequence of 7 by within the core site. The overlap region is at the center of symmetry of a palindromic sequence which appears in all four putative att core binding sites for Int. We confirm that the order of strand exchange is similar to that in phage λ.

Original languageEnglish
Pages (from-to)623-627
Number of pages5
JournalMolecular Genetics and Genomics
Issue number5
StatePublished - Sep 1994


  • Integrase Bacteriophage HK022
  • Lambdoid phages
  • Site-specific recombination


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