TY - JOUR
T1 - Population shift underlies Ca2+-induced regulatory transitions in the sodium-calcium exchanger (NCX)
AU - Giladi, Moshe
AU - Hiller, Reuben
AU - Hirsch, Joel A.
AU - Khananshvili, Daniel
PY - 2013/8/9
Y1 - 2013/8/9
N2 - Background: Ca2+ binding to the regulatory two-domain tandem (CBD12) activates ion transport in NCX. Results: Ca2+ binding to high affinity sites of CBD12 results in a population shift, where more constraint conformational states become highly populated. Conclusion: Ca 2+-induced population shift governs NCX activation with no significant contribution of global conformational changes in CBD alignment. Significance: Population shift may represent a general mechanism for regulating NCX.
AB - Background: Ca2+ binding to the regulatory two-domain tandem (CBD12) activates ion transport in NCX. Results: Ca2+ binding to high affinity sites of CBD12 results in a population shift, where more constraint conformational states become highly populated. Conclusion: Ca 2+-induced population shift governs NCX activation with no significant contribution of global conformational changes in CBD alignment. Significance: Population shift may represent a general mechanism for regulating NCX.
UR - http://www.scopus.com/inward/record.url?scp=84881436265&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.471698
DO - 10.1074/jbc.M113.471698
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C2 - 23798674
AN - SCOPUS:84881436265
SN - 0021-9258
VL - 288
SP - 23141
EP - 23149
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 32
ER -