Population shift underlies Ca2+-induced regulatory transitions in the sodium-calcium exchanger (NCX)

Moshe Giladi, Reuben Hiller, Joel A. Hirsch*, Daniel Khananshvili

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Background: Ca2+ binding to the regulatory two-domain tandem (CBD12) activates ion transport in NCX. Results: Ca2+ binding to high affinity sites of CBD12 results in a population shift, where more constraint conformational states become highly populated. Conclusion: Ca 2+-induced population shift governs NCX activation with no significant contribution of global conformational changes in CBD alignment. Significance: Population shift may represent a general mechanism for regulating NCX.

Original languageEnglish
Pages (from-to)23141-23149
Number of pages9
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
StatePublished - 9 Aug 2013

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