TY - JOUR
T1 - Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel™
AU - Lansky, Ephraim Philip
AU - Harrison, Gregory
AU - Froom, Paul
AU - Jiang, Wen G.
PY - 2005/4
Y1 - 2005/4
N2 - Four pure chemicals, ellagic acid (E), caffeic acid (C), luteolin (L) and punicic acid (P), all important components of the aqueous compartments or oily compartment of pomegranate fruit (Punica granatum), and each belonging to different representative chemical classes and showing known anticancer activities, were tested as potential inhibitors of in vitro invasion of human PC-3 prostate cancer cells in an assay employing Matrigel™ artificial membranes. All compounds significantly inhibited invasion when employed individually. When C, P, and L were equally combined at the same gross dosage (4 μ g/ml) as when the compounds were tested individually, a supradditive inhibition of invasion was observed, measured by the Kruskal-Wallis non-parametric test.
AB - Four pure chemicals, ellagic acid (E), caffeic acid (C), luteolin (L) and punicic acid (P), all important components of the aqueous compartments or oily compartment of pomegranate fruit (Punica granatum), and each belonging to different representative chemical classes and showing known anticancer activities, were tested as potential inhibitors of in vitro invasion of human PC-3 prostate cancer cells in an assay employing Matrigel™ artificial membranes. All compounds significantly inhibited invasion when employed individually. When C, P, and L were equally combined at the same gross dosage (4 μ g/ml) as when the compounds were tested individually, a supradditive inhibition of invasion was observed, measured by the Kruskal-Wallis non-parametric test.
KW - Caffeic acid
KW - Conjugated fatty acid
KW - Ellagic acid
KW - Luteolin
KW - Punicic acid
UR - http://www.scopus.com/inward/record.url?scp=15244361547&partnerID=8YFLogxK
U2 - 10.1007/s10637-005-5856-7
DO - 10.1007/s10637-005-5856-7
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AN - SCOPUS:15244361547
SN - 0167-6997
VL - 23
SP - 121
EP - 122
JO - Investigational New Drugs
JF - Investigational New Drugs
IS - 2
ER -