Polytuftsin: A potential precursor for slow release of the phagocytosis stimulating peptide tuftsin

Ronit Surkis, Sara Rubinraut, Shlomo Dagan, Ester Tzehoval, Mati Fridkin, Rami Ben Yoseph, Raphael Catane

Research output: Contribution to journalArticlepeer-review

Abstract

1. 1. Polytuftsin-(-Thr-Lys-Pro-Arg-)-n, was synthesized through polycondensation of an aminofree and carboxyl-activated derivative of tuftsin, H2N-Thr-Lys(Z)-Pro-Arg(Tos)-OSu, following suitable deprotectoin and fractionation steps. 2. 2. Digestion of polytuftsin by trypsin, as well as by normal human serum, at 37°C, yielded free tuftsin. 3. 3. Polytuftsin affected the decreased formation of lung-metastasis, in B16 melanoma treated mice and prolonged the survival of animals more efficiently than tuftsin. 4. 4. Tuftsin was found to be totally degraded by serum enzymes within ~ 60 min at 37°C.

Original languageEnglish
Pages (from-to)193-195
Number of pages3
JournalInternational Journal of Biochemistry
Volume22
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

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