TY - JOUR
T1 - Polytuftsin
T2 - A potential precursor for slow release of the phagocytosis stimulating peptide tuftsin
AU - Surkis, Ronit
AU - Rubinraut, Sara
AU - Dagan, Shlomo
AU - Tzehoval, Ester
AU - Fridkin, Mati
AU - Ben Yoseph, Rami
AU - Catane, Raphael
N1 - Funding Information:
Acknowledgement-This work was supported by the Minerva Foundation, Munich, B.R.D. It forms part of the M.Sc. thesis of R. Surkis, Feinberg Graduate School of the Weizmann Institute of Science, 1988.
PY - 1990
Y1 - 1990
N2 - 1. 1. Polytuftsin-(-Thr-Lys-Pro-Arg-)-n, was synthesized through polycondensation of an aminofree and carboxyl-activated derivative of tuftsin, H2N-Thr-Lys(Z)-Pro-Arg(Tos)-OSu, following suitable deprotectoin and fractionation steps. 2. 2. Digestion of polytuftsin by trypsin, as well as by normal human serum, at 37°C, yielded free tuftsin. 3. 3. Polytuftsin affected the decreased formation of lung-metastasis, in B16 melanoma treated mice and prolonged the survival of animals more efficiently than tuftsin. 4. 4. Tuftsin was found to be totally degraded by serum enzymes within ~ 60 min at 37°C.
AB - 1. 1. Polytuftsin-(-Thr-Lys-Pro-Arg-)-n, was synthesized through polycondensation of an aminofree and carboxyl-activated derivative of tuftsin, H2N-Thr-Lys(Z)-Pro-Arg(Tos)-OSu, following suitable deprotectoin and fractionation steps. 2. 2. Digestion of polytuftsin by trypsin, as well as by normal human serum, at 37°C, yielded free tuftsin. 3. 3. Polytuftsin affected the decreased formation of lung-metastasis, in B16 melanoma treated mice and prolonged the survival of animals more efficiently than tuftsin. 4. 4. Tuftsin was found to be totally degraded by serum enzymes within ~ 60 min at 37°C.
UR - http://www.scopus.com/inward/record.url?scp=0025371860&partnerID=8YFLogxK
U2 - 10.1016/0020-711X(90)90183-4
DO - 10.1016/0020-711X(90)90183-4
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AN - SCOPUS:0025371860
VL - 22
SP - 193
EP - 195
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
SN - 1357-2725
IS - 2
ER -