Polymyositis as a manifestation of chronic graft-versus-host disease

Pablo Parker; Nelson J. Chao; Johnathan Ben-Ezra; Neal Slatkin; Harry Openshaw; Joyce C. Niland; Charles A. Linker; Brian S. Greffe; Ashwin Kashyap; Arturo Molina; Auayporn Nademanee; Margaret R. O'Donnell; Ina Planas; Khalil Sheibani; Eileen P. Smith; David S. Snyder; Ricardo Spielberger; Anthony S. Stein; Daniel E. Stepan; Karl G. Blume; Stephen J. Forman

doi:10.1097/00005792-199609000-00004

Polymyositis as a manifestation of chronic graft-versus-host disease

Pablo Parker^*, Nelson J. Chao, Johnathan Ben-Ezra, Neal Slatkin, Harry Openshaw, Joyce C. Niland, Charles A. Linker, Brian S. Greffe, Ashwin Kashyap, Arturo Molina, Auayporn Nademanee, Margaret R. O'Donnell, Ina Planas, Khalil Sheibani, Eileen P. Smith, David S. Snyder, Ricardo Spielberger, Anthony S. Stein, Daniel E. Stepan, Karl G. BlumeStephen J. Forman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

A syndrome indistinguishable from idiopathic polymyositis occurred in 11 patients as a manifestation of chronic GVHD. All patients had elevation of creatine phosphokinase (CPK). Immunohistology demonstrated the effector cells in the muscle infiltrates as cytotoxic T cells, a finding similar to idiopathic polymyositis. Polymyositis is a rarely reported complication of chronic graft-versus-host disease (GVHD) with only 8 cases described in the literature. We encountered this syndrome in a small but significant percentage of our patients with chronic GVHD. Polymyositis associated with chronic GVHD does not affect the overall prognosis for the patient. Moreover, polymyositis can be the only manifestation of chronic GVHD. Awareness of this complication is important because it can be confused with other causes of muscle weakness after bone marrow transplantation. Finally, prompt initiation of corticosteroid therapy results in a rapid improvement of the associated symptoms.

Original language	English
Pages (from-to)	279-285
Number of pages	7
Journal	Medicine
Volume	75
Issue number	5
DOIs	https://doi.org/10.1097/00005792-199609000-00004
State	Published - Sep 1996
Externally published	Yes

Funding

Funders	Funder number
National Cancer Institute	P01CA049605

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10.1097/00005792-199609000-00004

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Parker, P., Chao, N. J., Ben-Ezra, J., Slatkin, N., Openshaw, H., Niland, J. C., Linker, C. A., Greffe, B. S., Kashyap, A., Molina, A., Nademanee, A., O'Donnell, M. R., Planas, I., Sheibani, K., Smith, E. P., Snyder, D. S., Spielberger, R., Stein, A. S., Stepan, D. E., ... Forman, S. J. (1996). Polymyositis as a manifestation of chronic graft-versus-host disease. Medicine, 75(5), 279-285. https://doi.org/10.1097/00005792-199609000-00004

@article{0005da9be40f4c64b551bba5afe6e91a,

title = "Polymyositis as a manifestation of chronic graft-versus-host disease",

abstract = "A syndrome indistinguishable from idiopathic polymyositis occurred in 11 patients as a manifestation of chronic GVHD. All patients had elevation of creatine phosphokinase (CPK). Immunohistology demonstrated the effector cells in the muscle infiltrates as cytotoxic T cells, a finding similar to idiopathic polymyositis. Polymyositis is a rarely reported complication of chronic graft-versus-host disease (GVHD) with only 8 cases described in the literature. We encountered this syndrome in a small but significant percentage of our patients with chronic GVHD. Polymyositis associated with chronic GVHD does not affect the overall prognosis for the patient. Moreover, polymyositis can be the only manifestation of chronic GVHD. Awareness of this complication is important because it can be confused with other causes of muscle weakness after bone marrow transplantation. Finally, prompt initiation of corticosteroid therapy results in a rapid improvement of the associated symptoms.",

author = "Pablo Parker and Chao, {Nelson J.} and Johnathan Ben-Ezra and Neal Slatkin and Harry Openshaw and Niland, {Joyce C.} and Linker, {Charles A.} and Greffe, {Brian S.} and Ashwin Kashyap and Arturo Molina and Auayporn Nademanee and O'Donnell, {Margaret R.} and Ina Planas and Khalil Sheibani and Smith, {Eileen P.} and Snyder, {David S.} and Ricardo Spielberger and Stein, {Anthony S.} and Stepan, {Daniel E.} and Blume, {Karl G.} and Forman, {Stephen J.}",

year = "1996",

month = sep,

doi = "10.1097/00005792-199609000-00004",

language = "אנגלית",

volume = "75",

pages = "279--285",

journal = "Medicine",

issn = "0025-7974",

publisher = "Lippincott Williams and Wilkins Ltd.",

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Parker, P, Chao, NJ, Ben-Ezra, J, Slatkin, N, Openshaw, H, Niland, JC, Linker, CA, Greffe, BS, Kashyap, A, Molina, A, Nademanee, A, O'Donnell, MR, Planas, I, Sheibani, K, Smith, EP, Snyder, DS, Spielberger, R, Stein, AS, Stepan, DE, Blume, KG & Forman, SJ 1996, 'Polymyositis as a manifestation of chronic graft-versus-host disease', Medicine, vol. 75, no. 5, pp. 279-285. https://doi.org/10.1097/00005792-199609000-00004

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T1 - Polymyositis as a manifestation of chronic graft-versus-host disease

AU - Parker, Pablo

AU - Chao, Nelson J.

AU - Ben-Ezra, Johnathan

AU - Slatkin, Neal

AU - Openshaw, Harry

AU - Niland, Joyce C.

AU - Linker, Charles A.

AU - Greffe, Brian S.

AU - Kashyap, Ashwin

AU - Molina, Arturo

AU - Nademanee, Auayporn

AU - O'Donnell, Margaret R.

AU - Planas, Ina

AU - Sheibani, Khalil

AU - Smith, Eileen P.

AU - Snyder, David S.

AU - Spielberger, Ricardo

AU - Stein, Anthony S.

AU - Stepan, Daniel E.

AU - Blume, Karl G.

AU - Forman, Stephen J.

PY - 1996/9

Y1 - 1996/9

N2 - A syndrome indistinguishable from idiopathic polymyositis occurred in 11 patients as a manifestation of chronic GVHD. All patients had elevation of creatine phosphokinase (CPK). Immunohistology demonstrated the effector cells in the muscle infiltrates as cytotoxic T cells, a finding similar to idiopathic polymyositis. Polymyositis is a rarely reported complication of chronic graft-versus-host disease (GVHD) with only 8 cases described in the literature. We encountered this syndrome in a small but significant percentage of our patients with chronic GVHD. Polymyositis associated with chronic GVHD does not affect the overall prognosis for the patient. Moreover, polymyositis can be the only manifestation of chronic GVHD. Awareness of this complication is important because it can be confused with other causes of muscle weakness after bone marrow transplantation. Finally, prompt initiation of corticosteroid therapy results in a rapid improvement of the associated symptoms.

AB - A syndrome indistinguishable from idiopathic polymyositis occurred in 11 patients as a manifestation of chronic GVHD. All patients had elevation of creatine phosphokinase (CPK). Immunohistology demonstrated the effector cells in the muscle infiltrates as cytotoxic T cells, a finding similar to idiopathic polymyositis. Polymyositis is a rarely reported complication of chronic graft-versus-host disease (GVHD) with only 8 cases described in the literature. We encountered this syndrome in a small but significant percentage of our patients with chronic GVHD. Polymyositis associated with chronic GVHD does not affect the overall prognosis for the patient. Moreover, polymyositis can be the only manifestation of chronic GVHD. Awareness of this complication is important because it can be confused with other causes of muscle weakness after bone marrow transplantation. Finally, prompt initiation of corticosteroid therapy results in a rapid improvement of the associated symptoms.

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Polymyositis as a manifestation of chronic graft-versus-host disease

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