Polymorphs of tamoxifen citrate: Detailed structural characterization of the stable form

Israel Goldberg*, Yigal Becker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The structure of the stable polymorph of tamoxifen citrate (form B) has been analyzed by single crystal X‐ray diffraction [monoclinic, a = 15.998 (4), b = 21.964 (3), c = 8.624 (5) Å, β = 96.28 (3)°, space group P21/c]. The results include conformational details of the molecular structure as well as a description of the observed packing arrangement in the solid which is dominated by hydrogen‐bonding interactions between the ionic entities. The proton transfer to the nitrogen atom of tamoxifen is from the central carboxyl group of the citric acid. There is a satisfactory correlation between the solid infrared spectrum of the carboxylic functions and the asymmetric environment observed around them in the crystal lattice. Additional results obtained from thermal and spectral analyses suggest that the second polymorph of tamoxifen citrate (form A) represents a metastable form of this compound. The two polymorphs are characterized by their powder diffraction spectra.

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalJournal of Pharmaceutical Sciences
Issue number3
StatePublished - Mar 1987


Dive into the research topics of 'Polymorphs of tamoxifen citrate: Detailed structural characterization of the stable form'. Together they form a unique fingerprint.

Cite this