Polymorphisms of the p53 gene in women with ovarian or endometrial carcinoma

Shoshana Peller*, Rehuvit Halperin, David Schneider, Yulia Kopilova, Varda Rotter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The p53 gene is frequently mutated in various human tumors. Polymorphism is an additional genetic alteration observed in exons and introns of the p53 gene of normal tissues and tumors. Distributions of alleles of three common polymorphisms of the p53 gene; a 16 bp duplication in intron 3, codon 72 of exon 4 and a sequence in intron 6, were studied in peripheral white blood cells (WBC) of patients with ovarian or endometrial carcinomas. The analysis was performed by PCR and direct sequencing. The 100% linkage observed between the most common haplotypes of each polymorphism in healthy subjects was lower in the patients. A significant difference was observed between frequencies of genotype and haplotype combinations in patients with ovarian carcinoma and endometrial carcinoma. The incidence of heterozygosity was increased in ovarian carcinoma and decreased in endometrial carcinoma. Our results suggest that the p53 gene may be involved in susceptibility and predisposition to various cancers not only by mutations but also by preferential presentation of polymorphic alleles.

Original languageEnglish
Pages (from-to)193-197
Number of pages5
JournalOncology Reports
Volume6
Issue number1
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Endometrial carcinoma
  • Ovarian carcinoma
  • p53 polymorphism
  • p53 tumor suppressor gene

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