Polymorphism of tissue and serum amyloid A (AA and SAA) proteins in the mouse

  • P. D. Gorevic
  • , Y. Levo
  • , B. Frangione
  • , E. C. Franklin

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Amino acid sequence studies of the amino terminal 25 residues of amyloid A (AA) protein and the serum precursor (SAA) induced with casein or LPS indicate differences in the sequence at position 6 and significant heterogeneity at several other positions in SAA. These findings suggest that SAA is a polymorphic serum protein and raise the possibility that only certain forms of SAA are processed to the tissue amyloid fibril.

Original languageEnglish
Pages (from-to)138-140
Number of pages3
JournalJournal of Immunology
Volume121
Issue number1
StatePublished - 1978
Externally publishedYes

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