Poly(ester-anhydride) for controlled delivery of hydrophilic drugs

Diana E. Ickowicz, Ester Abtew, Wahid Khan, Ludmila Golovanevski, Noam Steinman, Carolyn F. Weiniger, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

Abstract

Injectable pasty polyester-anhydride based on sebacic acid and ricinoleic acid at a 30:70 w/w ratio, poly(sebacic-co-ricinoleic-ester-anhydride) 3:7, was synthesized from the esterification of ricinoleic acid on poly(sebacic acid) followed by polyanhydride condensation. The effect of castor oil, citric acid, and glycerol added at 1% w/w as branching agents was determined. Castor oil and citric acid increased the viscosity, while glycerol decreased the viscosity of the polymer. Constant release of gentamicin and thyrotropin-releasing hormone incorporated in the polymer paste was monitored during 28 days.

Original languageEnglish
Pages (from-to)127-139
Number of pages13
JournalJournal of Bioactive and Compatible Polymers
Volume31
Issue number2
DOIs
StatePublished - 1 Mar 2016
Externally publishedYes

Keywords

  • Drug delivery
  • gentamicin
  • poly(ester-anhydride)
  • ricinoleic acid
  • sebacic acid
  • thyrotropin-releasing hormone

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