Poly(ester-anhydride) for controlled delivery of hydrophilic drugs

Diana E. Ickowicz; Ester Abtew; Wahid Khan; Ludmila Golovanevski; Noam Steinman; Carolyn F. Weiniger; Abraham J. Domb

doi:10.1177/0883911515598796

Poly(ester-anhydride) for controlled delivery of hydrophilic drugs

Diana E. Ickowicz, Ester Abtew, Wahid Khan, Ludmila Golovanevski, Noam Steinman, Carolyn F. Weiniger, Abraham J. Domb^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Injectable pasty polyester-anhydride based on sebacic acid and ricinoleic acid at a 30:70 w/w ratio, poly(sebacic-co-ricinoleic-ester-anhydride) 3:7, was synthesized from the esterification of ricinoleic acid on poly(sebacic acid) followed by polyanhydride condensation. The effect of castor oil, citric acid, and glycerol added at 1% w/w as branching agents was determined. Castor oil and citric acid increased the viscosity, while glycerol decreased the viscosity of the polymer. Constant release of gentamicin and thyrotropin-releasing hormone incorporated in the polymer paste was monitored during 28 days.

Original language	English
Pages (from-to)	127-139
Number of pages	13
Journal	Journal of Bioactive and Compatible Polymers
Volume	31
Issue number	2
DOIs	https://doi.org/10.1177/0883911515598796
State	Published - 1 Mar 2016
Externally published	Yes

Keywords

Drug delivery
gentamicin
poly(ester-anhydride)
ricinoleic acid
sebacic acid
thyrotropin-releasing hormone

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10.1177/0883911515598796

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abstract = "Injectable pasty polyester-anhydride based on sebacic acid and ricinoleic acid at a 30:70 w/w ratio, poly(sebacic-co-ricinoleic-ester-anhydride) 3:7, was synthesized from the esterification of ricinoleic acid on poly(sebacic acid) followed by polyanhydride condensation. The effect of castor oil, citric acid, and glycerol added at 1% w/w as branching agents was determined. Castor oil and citric acid increased the viscosity, while glycerol decreased the viscosity of the polymer. Constant release of gentamicin and thyrotropin-releasing hormone incorporated in the polymer paste was monitored during 28 days.",

keywords = "Drug delivery, gentamicin, poly(ester-anhydride), ricinoleic acid, sebacic acid, thyrotropin-releasing hormone",

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AU - Ickowicz, Diana E.

AU - Abtew, Ester

AU - Khan, Wahid

AU - Golovanevski, Ludmila

AU - Steinman, Noam

AU - Weiniger, Carolyn F.

AU - Domb, Abraham J.

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KW - Drug delivery

KW - gentamicin

KW - poly(ester-anhydride)

KW - ricinoleic acid

KW - sebacic acid

KW - thyrotropin-releasing hormone

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ER -

Poly(ester-anhydride) for controlled delivery of hydrophilic drugs

Abstract

Keywords

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