Poland anomaly after in vitro fertilization

O. M. Avrech, P. Merlob, A. Neri, B. Kaplan, J. Ovadia, B. Fisch*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objectives: To describe an extremely rare anomaly in an infant born after IVF-ET, and to assess its possible relationship to the artificial reproductive technology. Design: Case report. Setting: Infertility and IVF Unit, in a tertiary academic medical center. Patient: A 31-year-old healthy patient with a 9-year history of secondary, unexplained infertility. Intervention: Standard IVF-ET treatment cycle, using GnRH-a (short protocol) and hMG for controlled ovarian hyperstimulation. Results: Poland anomaly (asymmetric thorax with absence of the right pectoralis major muscle, low set rudimentary right nipple, and very mild hypoplasia of the right upper limb) is described for the first time in an infant who is one of a trizygotic triplet after IVF treatment. Conclusions: In view of the currently held hypothesis concerning the pathogenesis of Poland anomaly, the possibility of a teratogen or an event related to the reproductive procedure as the cause of this anomaly seems unlikely.

Original languageEnglish
Pages (from-to)1268-1270
Number of pages3
JournalFertility and Sterility
Issue number6 I
StatePublished - 1994
Externally publishedYes


  • In vitro fertilization
  • Poland anomaly
  • malformation
  • triplet


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