Point of care testing in children undergoing cardiopulmonary bypass

Tal Tirosh-Wagner, Tzipi Strauss, Marina Rubinshtein, Ilia Tamarin, David Mishaly, Gideon Paret, Gili Kenet

Research output: Contribution to journalArticlepeer-review


Background: Excessive hemorrhage is a major complication after cardiac surgery requiring cardiopulmonary bypass (CPB). The aim of this study was to define the potential role of the cone and platelet analyzer (CPA) and the rotating thromboelastogram (ROTEM) point of care tests in children undergoing CPB. +Procedure: We prospectively studied 15 pediatric patients aged 1 month to 10 years. Blood count, blood coagulation tests (prothrombin time [PT], activated partial thromboplastin time, fibrinogen, thrombin time), CPA and ROTEM parameters were measured before and after CPB. Demographic and surgical data were recorded as were those on perioperative blood loss and blood product transfusion. +Results: Low body weight, longer duration on CPB and lower core body temperature were associated with an increased bleeding risk. The ROTEM test showed a significant prolongation of clotting time and decreased maximal clot firmness (MCF) postoperatively in children with increased bleeding. The coagulation parameters associated with increased bleeding were: prolonged PT, lower fibrinogen levels, prior to surgery, and lower MCF after surgery. CPA test findings were not associated with postoperative bleeding in our patients. +Conclusions: CPA did not serve as a prognostic tool for predicting bleeding risk in children undergoing CPB. The change in ROTEM's post-CPB results associated with bleeding tendency, and they may predict for poorer clot formation and stability.

Original languageEnglish
Pages (from-to)794-798
Number of pages5
JournalPediatric Blood and Cancer
Issue number5
StatePublished - May 2011


  • Cardiopulmonary bypass
  • Cone and platelet analyzer (CPA)
  • Congenital heart disease
  • Pediatric
  • Thromboelastography


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