Pneumococcal vaccination of patients with systemic lupus erythematosus: Effects on generation of autoantibodies

Ori Elkayam*, Daphna Paran, Michael Burke, Vera Zakut, Ronit Ben-Yitshak, Ira Litinsky, Dan Caspi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objectives: To assess the effect of vaccination against streptococcus pneumoniae on the generation of autoantibodies in patients with SLE. Materials and methods: Twenty-four consecutive patients with SLE were vaccinated against streptococcus pneumoniae. Assessment was performed the day of vaccination and 2 months later and included evaluation of disease activity using the SLEDAI, serum levels of ESR, CRP, C3 and C4. The sera of the patients were tested by ELISA for anti-dsDNA, anticardiolipin (IgG and IgM), anti-Sm, anti-nRNP, anti-Ro/SSA, and anti-La/SSB. Results: The mean age at enrollment into the study was 39, mean disease duration 6.9 years. The SLEDAI score (mean ± SD) was 4.41 ± 2.92 at the time of vaccination and 4.47 ± 3.11, 2 months apart. At the time of vaccination, 10 patients had anti-dsDNA, 2 patients had anti-Sm, 5 had anti-nRNP, and 9 had anti-Ro/SSA, 4 had anti-La/SSB, 4 had anticardiolipin IgG and IgM. Two months after vaccination, no change was observed in the proportion of patients with anti-Sm, anti-dsDNA, anti-RNP, anti-Ro/SSA and anticardiolipin IgM. A single patient developed anticardiolipin IgG and another one turned anti-RNP negative. Conclusions: Vaccination against streptococcus pneumoniae did not trigger the generation of autoantibodies and confirms the clinical safety of this vaccine in SLE patients.

Original languageEnglish
Pages (from-to)493-496
Number of pages4
Issue number7
StatePublished - Nov 2005


  • Autoantibodies
  • Pneumococcal vaccine
  • Streptococcus
  • Systemic lupus erythematosus


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