Platelet satellitism as presenting finding in mantle cell lymphoma. A case report

C. Cesca, J. Ben-Ezra, R. S. Riley

Research output: Contribution to journalArticlepeer-review

Abstract

Platelet satellitism surrounding polymorphonuclear neutrophils has been observed almost exclusively in EDTA-treated blood at room temperature. The mechanism underlying this phenomenon is not understood fully. We report a case of platelet rosetting around atypical lymphocytes in peripheral blood smears made from EDTA-treated and untreated blood. Flow cytometry of the peripheral blood sample and immunohistochemical stains of the subsequent bone marrow biopsy specimen revealed a monoclonal B-cell population positive for CD5, CD20, and cyclin D1 and negative for CD3 and CD23; cytogenetic findings revealed a complex karyotype that included t(11;14). These findings were consistent with mantle cell lymphoma. To our knowledge, the finding of platelet satellitism involving mantle cell lymphoma cells in peripheral blood has not been reported previously.

Original languageEnglish
Pages (from-to)567-570
Number of pages4
JournalAmerican Journal of Clinical Pathology
Volume115
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Mantle cell lymphoma
  • Platelet satellitism

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