Platelet poor plasma serotonin level in delinquent adolescents diagnosed with conduct disorder

Pavel Golubchik, Tamar Mozes, Yaffa Vered, Abraham Weizman

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Accumulating data indicate the involvement of the serotonergic system in adolescent aggression. The aim of this study was to examine the platelet-poor plasma (PPP) serotonin (5-HT) levels among delinquent adolescent boys with conduct disorder (CD) in comparison with normal controls. Method: PPP 5-HT levels were measured in 16 male delinquent CD adolescents from a correctional facility and in 14 normal male adolescent controls. Severity of aggressive behavior was assessed by the Child Behavior Checklist (CBCL) and the Overt Aggression Scale (OAS). Results: Delinquent CD adolescents had higher PPP 5-HT levels (about 3-fold) than the normal controls (27.68 ± 32.29 vs. 7.76 ± 4.23 ng/ml, respectively, p = 0.027). In the delinquent CD adolescents a significant correlation was found between the PPP 5-HT levels and the CBCL and OAS aggressive scores (r = 0.68, p = 0.0034 and r = 0.59, p = 0.016, respectively). Conclusions: Juvenile delinquency is associated with high PPP 5-HT levels. Modulation of 5-HT neurotransmission may have a role in the symptomatology and treatment of severe adolescent CD.

Original languageEnglish
Pages (from-to)1223-1225
Number of pages3
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume33
Issue number7
DOIs
StatePublished - 1 Oct 2009

Keywords

  • Adolescent
  • Aggression
  • Delinquency
  • Serotonin

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