Platelet phospholipid synthesis in Alzheimer's disease

Philip D. Kanof*, Richard C. Mohs, Joel Gross, Michael Davidson, Linda M. Bierer, Kenneth L. Davis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The rates of incorporation of [3H]choline and [3H]ethanolamine into membrane phospholipids of platelets from 22 drug-free Alzheimer's disease patients and 18 normal elderly controls were compared. No significant differences between groups were found. If alterations in lipid metabolism are involved in the pathophysiological processes underlying Alzheimer's disease, such alterations are not manifest in measures of radiolabeled base incorporation into platelet phospholipids.

Original languageEnglish
Pages (from-to)65-69
Number of pages5
JournalNeurobiology of Aging
Volume12
Issue number1
DOIs
StatePublished - 1991
Externally publishedYes

Funding

FundersFunder number
National Institute on AgingAG-05138, P01AG002219
Alzheimer's Disease Research Foundation

    Keywords

    • Alzheimer's disease
    • Choline
    • Ethanolamine
    • Phospholipids
    • Platelets

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