Platelet peripheral benzodiazepine receptors in repeated stress

Dalit E. Dar, Abraham Weizman, Leon Karp, Alexander Grinshpoon, Miri Bidder, Moshe Kotler, Sam Tyano, Avraham Bleich, Moshe Gavish*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


[3H]PK 11195 binding to platelet membranes and plasma stress hormones were studied in soldiers at the beginning of a parachute training course, following 6 days of preparatory exercises, and after the fourth actual parachute jump. A slight reduction (15%; NS in the number of peripheral benzodiazepine receptors (PBR) was detected at the end of the exercise period, prior to the first jump. Reduced (26%; P<0.05) density of PBR was observed immediately after the repeated actual jumps. Equilibrium dissociation constants were not affected by the stressful situation. Plasma cortisol and prolactin levels remained unaltered during the entire study period.

Original languageEnglish
Pages (from-to)341-346
Number of pages6
JournalLife Sciences
Issue number4
StatePublished - 1991


FundersFunder number
Technion V.P.R. Fund
U.S.-Israel Binational Science Foundation184-131


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