TY - JOUR
T1 - Platelet imipramine binding in patients with posttraumatic stress disorder before and after phenelzine treatment
AU - Weizman, Ronit
AU - Laor, Nathaniel
AU - Schujovitsky, Ayala
AU - Wolmer, Leo
AU - Abramovitz-Schnaider, Pnina
AU - Freudstein-Dan, Ariela
AU - Rehavi, Moshe
PY - 1996/7/31
Y1 - 1996/7/31
N2 - Posttraumatic stress disorder (PTSD) is frequently associated with major depressive disorder, and antidepressants have been reported to ameliorate PTSD symptoms in some patients. The present study assessed the number and affinity of platelet imipramine binding sites, as a marker of the serotonin transporter complex, in PTSD male patients (n = 10) before and after phenelzine treatment (30-60 mg/day, for 4 weeks) as well as in comparison to healthy controls (n = 10). In our sample, there was no evidence of a significant difference in the characteristics (B(max) and K(d)) of platelet [3H]imipramine binding between the PTSD patients and the controls and within PTSD patients before and after phenelzine treatment. Moreover, no beneficial effect of phenelzine was detected in the patients (as assessed by PTSD, anxiety, and depression scales).
AB - Posttraumatic stress disorder (PTSD) is frequently associated with major depressive disorder, and antidepressants have been reported to ameliorate PTSD symptoms in some patients. The present study assessed the number and affinity of platelet imipramine binding sites, as a marker of the serotonin transporter complex, in PTSD male patients (n = 10) before and after phenelzine treatment (30-60 mg/day, for 4 weeks) as well as in comparison to healthy controls (n = 10). In our sample, there was no evidence of a significant difference in the characteristics (B(max) and K(d)) of platelet [3H]imipramine binding between the PTSD patients and the controls and within PTSD patients before and after phenelzine treatment. Moreover, no beneficial effect of phenelzine was detected in the patients (as assessed by PTSD, anxiety, and depression scales).
KW - Affective disorder
KW - Anxiety
KW - Monoamine oxidase inhibitor
KW - Serotonin transporter
UR - http://www.scopus.com/inward/record.url?scp=0030608134&partnerID=8YFLogxK
U2 - 10.1016/0165-1781(96)02760-6
DO - 10.1016/0165-1781(96)02760-6
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AN - SCOPUS:0030608134
SN - 0165-1781
VL - 63
SP - 143
EP - 150
JO - Psychiatry Research
JF - Psychiatry Research
IS - 2-3
ER -