TY - JOUR
T1 - Platelet imipramine binding and plasma cortisol levels in Israeli civilians during the Gulf War
AU - Weizman, Ronit
AU - Gil-Ad, Irit
AU - Karp, Leon
AU - Laor, Nathaniel
AU - Barber, Yerachmiel
AU - Rehavi, Moshe
PY - 1992/7/15
Y1 - 1992/7/15
N2 - [3H] Imipramine binding to platelets and plasma cortisol levels were measured in nine Israeli civilians before, during, and after repeated missile attacks. Hamilton Anxiety Rating Scale (HARS), and Beck Depression Inventory (BDI) were similar before and during the war and decreased significantly after the war. A trend toward increase in platelet imipramine binding values was observed during the war when compared with the postwar values (19%; p = 0.056), and/or when compared with prewar values (26%; p = 0.063). However, one-way analysis of variance with repeated measures did not reveal a significant statistical difference [F (2,6) = p = 2.07; NS] among the three time points. A significant correlation was found between HARS score, but not BDI, and imipramine binding values in the prewar and postwar time points (r = 0.87; 0.71, respectively). Plasma cortisol levels did not alter significantly during the study period.
AB - [3H] Imipramine binding to platelets and plasma cortisol levels were measured in nine Israeli civilians before, during, and after repeated missile attacks. Hamilton Anxiety Rating Scale (HARS), and Beck Depression Inventory (BDI) were similar before and during the war and decreased significantly after the war. A trend toward increase in platelet imipramine binding values was observed during the war when compared with the postwar values (19%; p = 0.056), and/or when compared with prewar values (26%; p = 0.063). However, one-way analysis of variance with repeated measures did not reveal a significant statistical difference [F (2,6) = p = 2.07; NS] among the three time points. A significant correlation was found between HARS score, but not BDI, and imipramine binding values in the prewar and postwar time points (r = 0.87; 0.71, respectively). Plasma cortisol levels did not alter significantly during the study period.
UR - http://www.scopus.com/inward/record.url?scp=0026444095&partnerID=8YFLogxK
U2 - 10.1016/0006-3223(92)90020-Z
DO - 10.1016/0006-3223(92)90020-Z
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AN - SCOPUS:0026444095
SN - 0006-3223
VL - 32
SP - 170
EP - 178
JO - Biological Psychiatry
JF - Biological Psychiatry
IS - 2
ER -