To the Editor: Trip and colleagues (May 31 issue)* are to be complimented on their important findings regarding the prognostic value of spontaneous platelet aggregation (SPA). We would like, however, to note a number of reservations. Although the study found significant results in a cohort of 149 patients, only 27 women were included in the study, of whom only 5 were in the SPA-positive group. In the entire female group there were only two deaths and four cardiac events. We do not believe that significant results can be obtained from such a small sample, and suggest that the findings be.