TY - JOUR
T1 - Platelet function and its clinical significance in the myeloproliferative disorders
AU - Zeidman, Aliza
AU - Horowits, Alon
AU - Kanter, Pazit
AU - Stein, Gideon Y.
AU - Redlich, Ophra
AU - Cohen, Amos
AU - Mittelman, Moshe
PY - 2005/1
Y1 - 2005/1
N2 - The present study was aimed to investigate platelet function in myeloproliferative disease (MPD) and its clinical significance. We studied 28 patients with MPD [polycythaemia vera, essential thrombocythosis (ET) and agnogneic myeloid metaplasia with myelofibrosis]. The mean platelet count was 240×109/l. Patients with platelet count less than 70×109/l were excluded. The mean bleeding time (BT) was 2.7 minutes. Only 1 patient has prolonged BT of 8 minutes (normal range 1-4 minutes). Platelet aggregation (PA) was studied with epinephrine (Epi), ADP, arachidonic acid (AA), ristocetin and collagen. Overall 22 patients (79%) patients had PA abnormality compared to 20% in the control group, 59% had impaired Epi-induced PA, 32% demonstrated reduced ADP-induced PA. Arachidonic acid, ristocetin and collagen was decreased PA in 48%, 18% and 11% respectively. Patients with polycythaemia vera and essential thrombocytosis demonstrated a similar platelet function profile as the whole MPD series with the exception of spontaneous aggregation in patients with ET (83%) which correlates with their thrombosis tendency (p <0.049). In the present study of 28 MPD patients, PA abnormalities were relatively common including bleeding and thrombotic episodes, spontaneous aggregation was significantly higher and was correlated to thrombotic events especially in ET patients.
AB - The present study was aimed to investigate platelet function in myeloproliferative disease (MPD) and its clinical significance. We studied 28 patients with MPD [polycythaemia vera, essential thrombocythosis (ET) and agnogneic myeloid metaplasia with myelofibrosis]. The mean platelet count was 240×109/l. Patients with platelet count less than 70×109/l were excluded. The mean bleeding time (BT) was 2.7 minutes. Only 1 patient has prolonged BT of 8 minutes (normal range 1-4 minutes). Platelet aggregation (PA) was studied with epinephrine (Epi), ADP, arachidonic acid (AA), ristocetin and collagen. Overall 22 patients (79%) patients had PA abnormality compared to 20% in the control group, 59% had impaired Epi-induced PA, 32% demonstrated reduced ADP-induced PA. Arachidonic acid, ristocetin and collagen was decreased PA in 48%, 18% and 11% respectively. Patients with polycythaemia vera and essential thrombocytosis demonstrated a similar platelet function profile as the whole MPD series with the exception of spontaneous aggregation in patients with ET (83%) which correlates with their thrombosis tendency (p <0.049). In the present study of 28 MPD patients, PA abnormalities were relatively common including bleeding and thrombotic episodes, spontaneous aggregation was significantly higher and was correlated to thrombotic events especially in ET patients.
KW - Bleeding time
KW - Essential thrombocytosis
KW - Myeloproliferative disorders
KW - Platelet aggregation
KW - Polycythemia vera
UR - http://www.scopus.com/inward/record.url?scp=15244349338&partnerID=8YFLogxK
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AN - SCOPUS:15244349338
SN - 1108-2682
VL - 8
SP - 64
EP - 69
JO - HAEMA
JF - HAEMA
IS - 1
ER -