Platelet alpha2-adrenergic receptor function in psychiatric disorders

Philip D. Kanof, Celeste A. Johns, Michael Davidson, Larry J. Siever, Emil F. Coccaro, Kenneth L. Davis

Research output: Contribution to journalArticlepeer-review


The inhibitory effects of norepinephrine (NE) on the cyclic adenosine-3′,5′-monophosphate (cAMP) response to prostaglandin E1 (PGE1), a measure of α2-adrenergic receptor function, have been compared in platelets from drug-free schizophrenic patients, depressive patients, and normal controls. The absolute value of the inhibition by NE of the cAMP response to PGE1 was smaller in platelets from schizophrenic and depressive patients than in controls. However, this result was secondary to the smaller baseline platelet cAMP response to PGE1 in patients with these disorders. Effects of NE on cAMP production did not discriminate between actively ill and remitted patients with either schizophrenia or depression. Platelet α2-receptor sensitivity, as measured by the effects of NE on cAMP production, does not appear to be altered in these psychiatric disorders.

Original languageEnglish
Pages (from-to)11-22
Number of pages12
JournalPsychiatry Research
Issue number1
StatePublished - Jan 1988
Externally publishedYes


  • Schizophrenia
  • depression
  • platelet
  • α-receptor sensitivity


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