Platelet-activating factor-a possible mediator in the pathogenesis of ulcerative colitis

D. Rachmilewitz*, F. Karmeli, R. Eliakim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Release of platelet-activating factor (PAF) by cultured colonic mucosa of patients with ulcerative colitis and healthy controls was determined. Before stimulation with calcium ionophore or antihuman IgE, no PAF release by control mucosa and minimal PAF release by mucosa of the colitis patients were detected. After stimulation with calcium ionophore, PAF release was four to five times higher by colonic mucosa of the colitis patients than of the controls. After stimulation with antihuman IgE, PAF release was twice as high by colonic mucosa of colitis patients as by control mucosa. Prednisolone, sulphasalazine, and mesalazine inhibited PAF activity stimulated by calcium ionophore in a dose-dependent manner. The results suggest that the use of PAF antagonists in the treatment of ulcerative colitis should be investigated.

Original languageEnglish
Pages (from-to)19-21
Number of pages3
JournalScandinavian Journal of Gastroenterology
Issue numberS172
StatePublished - 1990
Externally publishedYes


  • Mesalazine
  • Platelet-activating factor
  • Prednisolone
  • Sulphasalazine
  • Ulcerative colitis


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