Plate diffusion assay as a rapid method for dosimetry of mutagens

T. E. Awerbuch, A. A. Stark

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


This paper presents a method for determining mutagenic concentrations of chemicals by using an agar diffusion assay. The method is based on the linear relationship between the amount of chemical placed at the center of the dish and the radius of the mutagenic zone. A brief theoretical discussion and experimental data confirming this relationship are given. Alkylating agents and mycotoxins were used to test the system. This method can be used to follow up decreased mutagenic potencies of solutions of unstable mutagens and to follow the production of mutagenic substances throughout fermentation.

Original languageEnglish
Pages (from-to)1127-1131
Number of pages5
JournalApplied and Environmental Microbiology
Issue number6
StatePublished - 1979
Externally publishedYes


Dive into the research topics of 'Plate diffusion assay as a rapid method for dosimetry of mutagens'. Together they form a unique fingerprint.

Cite this