The Cyprean Arc is a part of the plate boundary between Afro-Arabia and Eurasia in the Eastern Mediterranean. A re-examination of the geophysical properties of the Cyprean Arc together with an analysis of multichannel seismic reflection profiles now available in the Cyprean Arc area provides a clearer view of the tectonic setting and processes in this region. Seismic activity and a gravity anomaly indicate that a northward subduction of oceanic material related to the African Plate beneath the Turkish Plate is the mode of convergence along the western segment of the Cyprean Arc. Subduction is interrupted due to the collision of the Eratosthenes Seamount at the central segment of the Cyprean Arc, which forms a zone of intense deformation. The zone of deformation spreads away and disappears in the eastern segment of the Cyprean Arc. No signs for deformation have been found in this portion, either in the multichannel seismic reflection profiles, in the seismicity or in the bathymetry. The change in the mode of convergence and in the type of deformation along the Cyprean Arc is induced by crustal differences in the underthrusting plate. Interruption of subduction activity in one segment of the arc also affects the geometry of nearby segments and the processes over there.