@article{3e3cd2b552de45d99b10a2ceabd30fab,
title = "Plasmodium falciparum: Thiol status and growth in normal and glucose-6-phosphate dehydrogenase deficient human erythrocytes",
abstract = "The relationship of the thiol status of the human erythrocyte to the in vitro growth of Plasmodium falciparum in normal and in glucose-6-phosphate dehydrogenase (G6PD)-deficient red cells was investigated. Pretreatment with the thiol-oxidizing agent diamide led to inhibition of growth of P. falciparum in G6PD-deficient cells, but did not affect parasite growth in normal cells. Diamidetreated normal erythrocytes quickly regenerated intracellular glutathione (GSH) and regained normal membrane thiol status, whereas G6PD-deficient cells did not. Parasite invasion and intracellular development were affected under conditions in which intracellular GSH was oxidized to glutathione disulfide and membrane intrachain and interchain disulfides were produced. An altered thiol status in the G6PD-deficient erythrocytes could underlie the selective advantage of G6PD deficiency in the presence of malaria.",
keywords = "Diamide, Erythrocyte, Glucose-6-phosphate dehydrogenase (G6PD) deficiency, Malaria, human, Plasmodium falciparum, Protozoa, parasitic, Thiol status",
author = "Jacqueline Miller and Jacob Golenser and Spira, {Dan T.} and Kosower, {Nechama S.}",
note = "Funding Information: This study was supported by grants from The Lester Aronberg Foundation; from the Chief Scientist{\textquoteright}s office, Ministry of Health, Israel; and from the fund for basic research administered by the Israel Academy of Sciences and Humanities.",
year = "1984",
month = jun,
doi = "10.1016/0014-4894(84)90097-3",
language = "אנגלית",
volume = "57",
pages = "239--247",
journal = "Experimental Parasitology",
issn = "0014-4894",
publisher = "Academic Press Inc.",
number = "3",
}
