Plasmid-encoded VCC-1 β-lactamase in a clinical isolate of Aeromonas caviae

Darya Bychenko Banyas*, Mor Lurie-Weinberger, Reut Efrati Epchtien, Sivan Laviad Shitrit, Elizabeth Temkin, David Schwartz, Alona Keren-Paz, Yehuda Carmeli

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Vibrio cholerae carbapenemase (VCC-1) is a chromosomal encoded class A carbapenemase thus far reported in environmental Vibrio cholerae isolates. Here, we report the first isolation of a blaVCC-1-carrying Aeromonas caviae from a clinical sample in Israel. The isolate was resistant to all β-lactam agents, including carbapenems. The blaVCC-1 was located on a large plasmid. GC content suggests that the origin of the blaVCC-1 gene is neither Aeromonas nor Vibrio spp. but an unknown progenitor.

Original languageEnglish
JournalAntimicrobial Agents and Chemotherapy
Volume67
Issue number11
DOIs
StatePublished - Nov 2023

Keywords

  • Aeromonas
  • antibiotic resistance
  • bla
  • carbapenemases

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