Plasma total homocysteine levels, dietary vitamin B6 and folate intake in AD and healthy aging

E. H. Mizrahi, D. W. Jacobsen, S. M. Debanne, F. Traore, A. J. Lerner, R. P. Friedland, Grace J. Petot*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: To study the association between Alzheimer's disease (AD) and plasma total homocysteine (tHcy), dietary folate and vitamin B6. METHODS: 64 AD patients were matched by gender, age, and smoking status to 64 healthy controls, tHcy was determined using an automated immunoassay. Dietary patterns for three age periods (20-39, 40-59, and 60 + yrs) were assessed using a questionnaire adapted from the Block Health Habits and History Questionnaire. Respondents (cases by proxy) reported food frequencies, which were translated into estimated daily nutrient intakes. APOE genotype, cognitive performance (CDR, MMSE), blood lipids, and albumin were obtained for patients and controls. RESULTS: tHcy did not differ significantly between controls (11.5 ± 3.7 mmol/L) and AD patients (12.3 ± 4.3 mmol/L)(p=0.25). tHcy levels were not related in AD patients or controls to education, CDR, MMSE, blood lipids, albumin or ApoE genotype (p>0.15). There was a negative correlation between plasma tHcy and triglyceride levels in AD patients (p=0,023), but not in controls. AD patients consumed significantly less dietary vitamin B6 (p=0.05) and folate (p=0.001) after age 60 than controls. CONCLUSIONS: Although plasma tHcy levels were higher in cases than controls, this difference was not significant. tHcy levels were not related to cognitive status. Plasma tHcy was inversely correlated with triglyceride levels in AD patients but not in controls.

Original languageEnglish
Pages (from-to)160-165
Number of pages6
JournalJournal of Nutrition, Health and Aging
Volume7
Issue number3
StatePublished - 2003
Externally publishedYes

Funding

FundersFunder number
National Institute on AgingP50AG008012
National Heart, Lung, and Blood InstituteR01HL052234

    Keywords

    • Aging
    • Alzheimer's Disease
    • Elderly
    • Folate intake
    • Homocysteine level
    • Nutrition
    • Vitamin B6

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