Abstract
The study was conducted to determine whether altered plasma concentrations of soluble selectins are involved in the pathogenesis of pre-eclampsia. Maternal plasma samples were collected from 20 patients with pre-eclampsia, and from 20 matched normotensive patients with uncomplicated pregnancies. Samples were assayed for soluble endothelial selectin (sES), platelet selectin (sPS) and leukocyte selectin (sLS) by specific enzyme-linked immunosorbent assay. The three soluble selectins were detectable in the plasma of all pre-eclamptic and control patients. The mean plasma concentrations of sPS and sLS were comparable between the groups. However, the mean plasma concentration of sES was significantly higher in the pre-eclamptic group compared with the control group (61 ng/ml ± 30 ng/ml compared with 40 ng/ml ± 17 ng/ml; P < 0.01). The selective increased plasma concentrations of sES in patients with pre-eclampsia provide specific evidence for endothelial activation and may reflect distinct pathways for neutrophil activation in pre-eclampsia.
Original language | English |
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Pages (from-to) | 3537-3541 |
Number of pages | 5 |
Journal | Human Reproduction |
Volume | 13 |
Issue number | 12 |
DOIs | |
State | Published - 1998 |
Keywords
- Endothelial activation
- Neutrophil activation
- Platelet activation
- Pre-eclampsia
- Soluble selectins