Plasma soluble endothelial selectin is elevated in women with pre-eclampsia

Y. Daniel, M. J. Kupferminc, A. Baram, A. J. Jaffa, I. Wolman, M. Shenhav, J. B. Lessing*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

The study was conducted to determine whether altered plasma concentrations of soluble selectins are involved in the pathogenesis of pre-eclampsia. Maternal plasma samples were collected from 20 patients with pre-eclampsia, and from 20 matched normotensive patients with uncomplicated pregnancies. Samples were assayed for soluble endothelial selectin (sES), platelet selectin (sPS) and leukocyte selectin (sLS) by specific enzyme-linked immunosorbent assay. The three soluble selectins were detectable in the plasma of all pre-eclamptic and control patients. The mean plasma concentrations of sPS and sLS were comparable between the groups. However, the mean plasma concentration of sES was significantly higher in the pre-eclamptic group compared with the control group (61 ng/ml ± 30 ng/ml compared with 40 ng/ml ± 17 ng/ml; P < 0.01). The selective increased plasma concentrations of sES in patients with pre-eclampsia provide specific evidence for endothelial activation and may reflect distinct pathways for neutrophil activation in pre-eclampsia.

Original languageEnglish
Pages (from-to)3537-3541
Number of pages5
JournalHuman Reproduction
Volume13
Issue number12
DOIs
StatePublished - 1998

Keywords

  • Endothelial activation
  • Neutrophil activation
  • Platelet activation
  • Pre-eclampsia
  • Soluble selectins

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