TY - JOUR
T1 - Plasma-mediated ablation
T2 - an optical tool for submicrometer surgery on neuronal and vascular systems
AU - Tsai, Philbert S.
AU - Blinder, Pablo
AU - Migliori, Benjamin J.
AU - Neev, Joseph
AU - Jin, Yishi
AU - Squier, Jeffrey A.
AU - Kleinfeld, David
PY - 2009/2
Y1 - 2009/2
N2 - Plasma-mediated ablation makes use of high energy laser pulses to ionize molecules within the first few femtoseconds of the pulse. This process leads to a submicrometer-sized bubble of plasma that can ablate tissue with negligible heat transfer and collateral damage to neighboring tissue. We review the physics of plasma-mediated ablation and its use as a tool to generate targeted insults at the subcellular level to neurons and blood vessels deep within nervous tissue. Illustrative examples from axon regeneration and microvascular research highlight the utility of this tool. We further discuss the use of ablation as an integral part of automated histology.
AB - Plasma-mediated ablation makes use of high energy laser pulses to ionize molecules within the first few femtoseconds of the pulse. This process leads to a submicrometer-sized bubble of plasma that can ablate tissue with negligible heat transfer and collateral damage to neighboring tissue. We review the physics of plasma-mediated ablation and its use as a tool to generate targeted insults at the subcellular level to neurons and blood vessels deep within nervous tissue. Illustrative examples from axon regeneration and microvascular research highlight the utility of this tool. We further discuss the use of ablation as an integral part of automated histology.
UR - http://www.scopus.com/inward/record.url?scp=65449139222&partnerID=8YFLogxK
U2 - 10.1016/j.copbio.2009.02.003
DO - 10.1016/j.copbio.2009.02.003
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AN - SCOPUS:65449139222
SN - 0958-1669
VL - 20
SP - 90
EP - 99
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
IS - 1
ER -