TY - JOUR
T1 - Plasma interleukin-12 is elevated in patients with preeclampsia
AU - Daniel, Yair
AU - Kupferminc, Michael J.
AU - Baram, Amiram
AU - Jaffa, Ariel J.
AU - Fait, Gideon
AU - Wolman, Igal
AU - Lessing, Joseph B.
PY - 1998
Y1 - 1998
N2 - PROBLEM: Abnormal immune activation has been suggested as a contributor to the development of preeclampsia. We hypothesized that intact interleukin (IL)-12 directly, or through its main mediator, interferon (IFN)-γ, contributes to the altered immune response observed in preeclampsia. METHOD OF STUDY: Plasma samples were collected from 20 patients with preeclampsia and 20 normotensive patients with uncomplicated pregnancies who were matched with the preeclamptic patients by age, gestational age, and parity. Samples were collected before the onset of labor, induction, or medical intervention. The samples were assayed for IL-12 and IFN-γ by specific enzyme-linked immunoassays. RESULTS: IL-12 was detected in 35% of the preeclamptic patients and in 5% of the patients with normal pregnancies (P < 0.01). The detection rate and mean concentration of IFN-γ were comparable in both groups. CONCLUSION: Intact plasma IL-12 is detected more frequently in preeclamptic patients, suggesting the involvement of this cytokine in the enhanced immune response observed in preeclampsia.
AB - PROBLEM: Abnormal immune activation has been suggested as a contributor to the development of preeclampsia. We hypothesized that intact interleukin (IL)-12 directly, or through its main mediator, interferon (IFN)-γ, contributes to the altered immune response observed in preeclampsia. METHOD OF STUDY: Plasma samples were collected from 20 patients with preeclampsia and 20 normotensive patients with uncomplicated pregnancies who were matched with the preeclamptic patients by age, gestational age, and parity. Samples were collected before the onset of labor, induction, or medical intervention. The samples were assayed for IL-12 and IFN-γ by specific enzyme-linked immunoassays. RESULTS: IL-12 was detected in 35% of the preeclamptic patients and in 5% of the patients with normal pregnancies (P < 0.01). The detection rate and mean concentration of IFN-γ were comparable in both groups. CONCLUSION: Intact plasma IL-12 is detected more frequently in preeclamptic patients, suggesting the involvement of this cytokine in the enhanced immune response observed in preeclampsia.
KW - Cytokines
KW - IFN-γ
KW - Immune system
KW - Interleukin-12
KW - Preeclampsia
UR - http://www.scopus.com/inward/record.url?scp=0031860898&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0897.1998.tb00372.x
DO - 10.1111/j.1600-0897.1998.tb00372.x
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C2 - 9645268
AN - SCOPUS:0031860898
SN - 8755-8920
VL - 39
SP - 376
EP - 380
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 6
ER -