Plasma homovanillic acid concentration and the severity of schizophrenic illness

Kenneth L. Davis; Michael Davidson; Richard C. Mohs; Kenneth S. Kendler; Bonnie M. Davis; Celeste A. Johns; Yvonne Denigris; Thomas B. Horvath

doi:10.1126/science.3975630

Plasma homovanillic acid concentration and the severity of schizophrenic illness

Kenneth L. Davis, Michael Davidson, Richard C. Mohs, Kenneth S. Kendler, Bonnie M. Davis, Celeste A. Johns, Yvonne Denigris, Thomas B. Horvath

Clinical Departments

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

Concentrations of plasma homovanillic acid before treatment were highly correlated with global severity of illness in schizophrenic patients, both before and after treatment. In contrast, a fixed dose of haloperidol did not affect those concentrations. Thus, in patients with a diagnosis of schizophrenia, plasma homovanillic acid may reflect the severity of illness, but not be influenced by short-term pharmacological perturbations by neuroleptics.

Original language	English
Pages (from-to)	1601-1602
Number of pages	2
Journal	Science
Volume	227
Issue number	4694
DOIs	https://doi.org/10.1126/science.3975630
State	Published - 1985

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title = "Plasma homovanillic acid concentration and the severity of schizophrenic illness",

abstract = "Concentrations of plasma homovanillic acid before treatment were highly correlated with global severity of illness in schizophrenic patients, both before and after treatment. In contrast, a fixed dose of haloperidol did not affect those concentrations. Thus, in patients with a diagnosis of schizophrenia, plasma homovanillic acid may reflect the severity of illness, but not be influenced by short-term pharmacological perturbations by neuroleptics.",

author = "Davis, {Kenneth L.} and Michael Davidson and Mohs, {Richard C.} and Kendler, {Kenneth S.} and Davis, {Bonnie M.} and Johns, {Celeste A.} and Yvonne Denigris and Horvath, {Thomas B.}",

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AU - Johns, Celeste A.

AU - Denigris, Yvonne

AU - Horvath, Thomas B.

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AB - Concentrations of plasma homovanillic acid before treatment were highly correlated with global severity of illness in schizophrenic patients, both before and after treatment. In contrast, a fixed dose of haloperidol did not affect those concentrations. Thus, in patients with a diagnosis of schizophrenia, plasma homovanillic acid may reflect the severity of illness, but not be influenced by short-term pharmacological perturbations by neuroleptics.

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Plasma homovanillic acid concentration and the severity of schizophrenic illness

Abstract

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