@article{ef775d61e0904baf925b9bba802362fb,
title = "Plasma homocysteine, vitamin B12 and folate in Alzheimer's patients and healthy Arabs in Israel",
abstract = "High plasma homocysteine (tHcy) is a risk factor for cardiovascular disease and stroke and Alzheimer's disease (AD). An inverse relationship has been reported between tHcy and plasma B12 and folate levels. Seventy-nine AD patients and 156 controls from three Arab villages in northern Israel participated. Plasma tHcy, B12 and folate levels were determined. Data were analyzed using univariate statistical tests and logistical regression with confounders. tHcy was significantly higher in AD patients (20.6±8.7 μmol/l) than in controls (16.4±6.5 μmol/l) (p=0.03) after correction for year of birth, gender and smoking status. Plasma B12 (322.9±136.0/350. 5±175.3 pmol/l) and plasma folate (4.5±3.8/4.9±2.6 nmol/l) levels did not differ significantly between AD patients and controls. Subjects in the highest tHcy tertile or in the lowest B12 and folate tertiles did not have greater risk to develop AD. In this population residing in Arab villages in northern Israel, tHcy levels were significantly higher among AD patients than in controls. Plasma B12 and folate levels were lower among cases but were not significant. There was not a significant association between plasma tHcy, B12 and folate levels in controls or AD patients. High levels of tHcy may suggest the need for folate and vitamin B12 supplementation in this population.",
keywords = "Alzheimer's disease, Arab villages, Folate, Homocysteine, Vitamin B12",
author = "Mizrahi, {E. H.} and A. Bowirrat and Jacobsen, {D. W.} and Korczyn, {A. D.} and F. Traore and Petot, {G. J.} and Lerner, {A. J.} and Debanne, {S. M.} and A. Adunsky and Dibello, {P. M.} and Friedland, {R. P.}",
note = "Funding Information: This work was supported in part by the: National Institutes of Health (U01-AG17173), The Institute for the Study of Aging, Philip Morris, The GOJO, Akron, OH, The Fullerton Family Charitable Trust and The Nickman Family.",
year = "2004",
month = dec,
day = "15",
doi = "10.1016/j.jns.2004.08.011",
language = "אנגלית",
volume = "227",
pages = "109--113",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier B.V.",
number = "1",
}
