TY - JOUR
T1 - Plasma cyclic adenosine 3′5′-monophosphate (AMP) levels in acute myocardial infarction
AU - Rabinowitz, Babeth
AU - Kligerman, Miriam
AU - Parmley, William W.
N1 - Funding Information:
From the Departments of Cardiology and Biochemistry, Cedars-Sinai Medical Center, Los Angeles, Calif. This work was supported in part by Contract PH-43-68-1333 under the Myocardial Infarction Research Program, National Heart and Lung Institute, National Institutes of Health, Bethesda. Md. Manuscript accepted January 3, 1974. l Fellow, Los Angeles County Heart Association. t Work performed during the tenure of an Established Investigatorship of the Amerkxn Heart Association.
PY - 1974/7
Y1 - 1974/7
N2 - Plasma cyclic adenosine 3′5′-monophosphate (AMP) levels were measured in 44 patients with acute myocardial infarction, 33 patients with other cardiac and noncardiac diseases and 20 normal volunteers. The normal range of cyclic AMP was 4 to 16 picomoles/ml. The 35 surviving patients with acute myocardial infarction tended to have a slightly increased level of plasma cyclic AMP during the first 24 hours with a subsequent return to normal; the 9 nonsurvivors had abnormally high levels of cyclic AMP. An inverse correlation was found between cyclic AMP levels and stroke work index, and plasma cyclic AMP levels were of equal or better prognostic value than stroke work index. Plasma cyclic AMP levels were in the normal range in patients without acute myocardial infarction. Thus, very high levels of plasma cyclic AMP, found in patients with fatal myocardial infarction, appear to have clinical significance.
AB - Plasma cyclic adenosine 3′5′-monophosphate (AMP) levels were measured in 44 patients with acute myocardial infarction, 33 patients with other cardiac and noncardiac diseases and 20 normal volunteers. The normal range of cyclic AMP was 4 to 16 picomoles/ml. The 35 surviving patients with acute myocardial infarction tended to have a slightly increased level of plasma cyclic AMP during the first 24 hours with a subsequent return to normal; the 9 nonsurvivors had abnormally high levels of cyclic AMP. An inverse correlation was found between cyclic AMP levels and stroke work index, and plasma cyclic AMP levels were of equal or better prognostic value than stroke work index. Plasma cyclic AMP levels were in the normal range in patients without acute myocardial infarction. Thus, very high levels of plasma cyclic AMP, found in patients with fatal myocardial infarction, appear to have clinical significance.
UR - http://www.scopus.com/inward/record.url?scp=0016243426&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(74)90085-X
DO - 10.1016/0002-9149(74)90085-X
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AN - SCOPUS:0016243426
SN - 0002-9149
VL - 34
SP - 7
EP - 11
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 1
ER -