Placental vascular pathology as a mechanism of disease in pregnancy complications

Michal Kovo*, Letizia Schreiber, Jacob Bar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Inadequate placental development results in pregnancy complications. The extent and the degree of defective deep placentation may explain why a similar insult would result in different clinical presentations. The relative new categorization of the placental lesions, separating the non-infectious lesions into lesions that are consistent with maternal and fetal circulation abnormalities, and the infectious lesions into maternal and fetal inflammatory responses, provides us an additional tool to determine the placental maternal and fetal role in the various pregnancy complications. Placental vascular lesions are different in pregnancies complicated by preeclampsia (predominant maternal vascular supply lesions), by fetal growth restriction (FGR) (predominant fetal vascular supply lesions), and by preeclampsia with FGR (both maternal and fetal compartments are involved). Moreover, placental vascular lesions are also different in relation to gestational age at disease onset, as in early- and late-onset preeclampsia, FGR, Fetal death and preterm labor.

Original languageEnglish
Pages (from-to)S18-S21
JournalThrombosis Research
Issue numberSUPPL.1
StatePublished - Jan 2013


  • Fetal growth restriction
  • Histopathology
  • Placenta
  • Preeclampsia
  • Preterm labor
  • Vascular lesions


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