TY - JOUR
T1 - Placental transfer of measles antibodies
T2 - Effect of gestational age and maternal vaccination status
AU - Linder, Nehama
AU - Tallen-Gozani, Esther
AU - German, Boris
AU - Duvdevani, Poriya
AU - Ferber, Asaf
AU - Sirota, Lea
N1 - Funding Information:
This article is dedicated to our late, generous and beloved benefactor, Helen Schneider. The authors wish to thank Mrs. Pearl Lilos of the Department of Statistics, Tel Aviv University for excellent statistical analysis, and the Schneider Children’s Medical Center of Israel for the grant supporting this work.
PY - 2004/3/29
Y1 - 2004/3/29
N2 - Despite nationwide measles vaccination coverage in Israel of over 90%, repeated outbreaks of measles have spread from isolated communities with poor immunization uptake. Some severely affected individuals were children under 1 year of age, including premature infants. We evaluated the serological status of 195 newborn infants and their 161 mothers divided into four groups: vaccinated mothers (VMs) and premature infants, VM and full term infants, naturally immunized mothers (NIMs) and premature infants, NIM and full term infants. Maternal and cord blood measles antibody titers were determined by haemagglutination inhibition (HI) test and microneutralization test (mNT). Fewer than 40% of preterm infants of VM and less then 70% of preterm infants of NIM had protective titers at birth. The results of this study may aid in formulating new measles vaccination recommendations for preterm infants.
AB - Despite nationwide measles vaccination coverage in Israel of over 90%, repeated outbreaks of measles have spread from isolated communities with poor immunization uptake. Some severely affected individuals were children under 1 year of age, including premature infants. We evaluated the serological status of 195 newborn infants and their 161 mothers divided into four groups: vaccinated mothers (VMs) and premature infants, VM and full term infants, naturally immunized mothers (NIMs) and premature infants, NIM and full term infants. Maternal and cord blood measles antibody titers were determined by haemagglutination inhibition (HI) test and microneutralization test (mNT). Fewer than 40% of preterm infants of VM and less then 70% of preterm infants of NIM had protective titers at birth. The results of this study may aid in formulating new measles vaccination recommendations for preterm infants.
KW - Premature
KW - Seropositivity
KW - Vaccination
UR - http://www.scopus.com/inward/record.url?scp=1842456843&partnerID=8YFLogxK
U2 - 10.1016/j.vaccine.2003.10.009
DO - 10.1016/j.vaccine.2003.10.009
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AN - SCOPUS:1842456843
SN - 0264-410X
VL - 22
SP - 1509
EP - 1514
JO - Vaccine
JF - Vaccine
IS - 11-12
ER -
