Placental isoferritin in gestational diabetes mellitus

Jacob Bar, Moshe Hod, Ron Maymon, Chaya Moroz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background. Serum placental isoferritin, an immunosuppressive cytokine like protein, was found to be elevated in type I diabetes at diagnosis and low in high risk pregnant women. Further to this observation, the possible role of this placental product was assessed in pregnant women with gestational diabetes mellitus. Methods. A comparative study. One hundred and seventy-four pregnant women were included in the study: 28 were diagnosed as gestational diabetes mellitus and 146 were normal controls. Main outcome measures. Samples for serum placental ferritin were measured in the second and third trimesters of pregnancy. Results. Serum placental isoferritin values were significantly lower in the second trimester of pregnancy in the gestational diabetes mellitus group (9.4 ± 2.6 U/ml) as compared with the control group (21.5 ± 2.2 U/ml, p = 0.0001), and were also significantly lower in the third trimester (3.7 ± 1.9 vs. 19 ± 2.6 U/ml, respectively, p = 0.00001). Conclusions. Low serum PLF values detected in gestational diabetes mellitus may reflect placental function and be related to insulin treatment.

Original languageEnglish
Pages (from-to)504-507
Number of pages4
JournalActa Obstetricia et Gynecologica Scandinavica
Issue number5
StatePublished - 1998


  • Gestational diabetes mellitus
  • Placental isoferritin


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