Placental histopathology in IVF pregnancies resulting from the transfer of frozen-thawed embryos compared with fresh embryos

Yossi Mizrachi*, Ariel Weissman, Gili Buchnik Fater, Maya Torem, Eran Horowitz, Letizia Schreiber, Arieh Raziel, Jacob Bar, Michal Kovo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Purpose: To study whether placentas of singleton pregnancies conceived after fresh embryo transfer (ET) contain more histopathological lesions compared with placentas of singleton pregnancies conceived after frozen-thawed embryo transfer (FET). Methods: A prospective cohort study of placental histopathology in 131 women with singleton IVF pregnancies who delivered at a single medical center, between December 2017 and May 2019. The prevalence of different placental histopathology lesions was compared between women who conceived after fresh ET and FET. Results: Women who conceived after fresh ET (n = 74) did not differ from women who conceived after FET (n = 57) with regard to maternal age, BMI, nulliparity, or infertility diagnosis. Gestational week at delivery was lower in pregnancies conceived after fresh ET (38.5 vs. 39.2 weeks, respectively, p = 0.04), and a trend for a lower birthweight following fresh ET was noted (3040 vs. 3216 g, respectively, p = 0.053). However, placental histopathology analysis from pregnancies conceived after fresh ET was comparable to pregnancies conceived after FET, with regard to the prevalence of maternal vascular malperfusion lesions (45.9% vs. 50.9%, respectively, p = 0.57), fetal vascular malperfusion lesions (17.6% vs. 21.1, p = 0.61), acute inflammatory response lesions (28.4% vs. 28.1%, respectively, p = 0.96), and chronic inflammatory response lesions (13.5% vs. 8.8%, respectively, p = 0.48). Conclusion: Placental histopathology did not differ between IVF pregnancies conceived after fresh and frozen ET. These results are reassuring for clinicians and patients who wish to pursue with transferring fresh embryos.

Original languageEnglish
Pages (from-to)1155-1162
Number of pages8
JournalJournal of Assisted Reproduction and Genetics
Volume37
Issue number5
DOIs
StatePublished - 1 May 2020

Keywords

  • Fresh embryo transfer
  • Frozen embryo transfer
  • IVF
  • Pathology
  • Placenta

Fingerprint

Dive into the research topics of 'Placental histopathology in IVF pregnancies resulting from the transfer of frozen-thawed embryos compared with fresh embryos'. Together they form a unique fingerprint.

Cite this