Placental angiopoietin-1 and angiopoietin-2 expression and correlation with birth weight in twins

Ruth Z. Birk*, Eliezer Burstein, Arnon Wiznitzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To study the expression of angiopoietin 1 (Ang1) and angiopoietin 2 (Ang2) in human placentas of dizygotic dichorionic twins in relation to fetal growth. Study design. Placentas from dizygotic-dichorionic twins (n = 14) obtained from normal uncomplicated pregnancies were collected immediately after delivery. A quantitative assessment of the placental expression of Ang1 and Ang2 was done using quantitative PCR. Birth weight and anthropometric parameters were measured. Statistical analysis was preformed. Results. Ang1 and Ang2 were expressed in the placentas. We found a significant positive correlation between birth weight and expression of both Ang1 and Ang2 (p < 0.009, p < 0.011, respectively). In addition, there was a significant positive correlation between skin fold, BMI and Ang1 expression (p < 0.0001 and p < 0.01, respectively). Conclusion. A positive correlation between twin birth weight and placental angiogenesis was found. We suggest that placental expression of Ang1 and Ang2 may have an important role in fetal growth in twin pregnancy.

Original languageEnglish
Pages (from-to)337-342
Number of pages6
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume17
Issue number5
DOIs
StatePublished - May 2005
Externally publishedYes

Keywords

  • Angiogenesis
  • Angiopoietin 1
  • Angiopoietin 2
  • Dizygotic dichorionic twins
  • Placenta

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