Pituitary and bilateral adrenal enlargement: An unusual presentation of hepatocellular carcinoma

D. Hirsch*, C. A. Benbassat, T. Drozd, E. Okon, I. Blum

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Pituitary metastases account for about 1% of operated pituitary lesions. Most derive from primaries in the breast or lung. Pituitary metastases from hepatocellular carcinoma (HCC) have rarely been reported. We describe a patient in whom headache and left external ophthalmoplegia were the only presenting signs of a clinically silent and radiographically undetectable HCC, that had metastasized to the pituitary and both adrenal glands. Pituitary histology and adrenal needle biopsy failed to establish the final diagnosis, which was reached only after surgical exploration of the abdomen. This case illustrates the difficulties encountered in the histopathological diagnosis of pituitary metastasis and the need for good clinical judgment when confronting pituitary tumors with atypical features.

Original languageEnglish
Pages (from-to)454-458
Number of pages5
JournalJournal of Endocrinological Investigation
Issue number7
StatePublished - 2005


  • Adrenal tumor
  • Hepatocellular carcinoma
  • Metastasis
  • Pituitary


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