TY - JOUR
T1 - PIGMENT EPITHELIAL DETACHMENT in AGE-RELATED MACULAR DEGENERATION
T2 - Long-Term Visual Acuity May Improve with Higher Injection Index
AU - Gui, Wei
AU - Au, Adrian
AU - Rabina, Gilad
AU - Kapelushnik, Noa
AU - Cohen, Shai
AU - Masarwa, Dua
AU - Hosseini, Hamid
AU - Heilweil, Gad
AU - Schwartz, Shulamit
AU - Loewenstein, Anat
AU - Schwartz, Steven D.
N1 - Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Purpose:To define injection index (II) and assess its impact on visual acuity (VA) in pigment epithelial detachment from age-related macular degeneration over 5 years.Methods:Injection index is defined as the mean anti-vascular endothelial growth factor injections per year from presentation. A retrospective study of 256 eyes in 213 patients was performed. Patients were stratified by II (high: ≥9, low: <9).Results:Baseline characteristics showed no differences across II groups. Mean (range) follow-up, in years, was 5.02 (1.04-12.74) for all patients. Mean logMAR VA (Snellen VA) were 0.60 (20/80) and 0.56 (20/73) at baseline, 0.52 (20/66) and 0.59 (20/78) at Year 1, 0.45 (20/56) and 0.67 (20/94) at Year 2, 0.38 (20/48) and 0.66 (20/91) at Year 3, 0.41 (20/51) and 0.89 (20/155) at Year 4, and 0.35 (20/45) and 0.79 (20/123) at Year 5 for the high and low II groups, respectively. Linear regression analysis showed a gain of 0.5 approxETDRS letters with each additional injection per year.Conclusion:Increased II was associated with better mean VA, suggesting that long-term continuous vascular endothelial growth factor suppression may improve VA in eyes thought to carry poor prognoses.
AB - Purpose:To define injection index (II) and assess its impact on visual acuity (VA) in pigment epithelial detachment from age-related macular degeneration over 5 years.Methods:Injection index is defined as the mean anti-vascular endothelial growth factor injections per year from presentation. A retrospective study of 256 eyes in 213 patients was performed. Patients were stratified by II (high: ≥9, low: <9).Results:Baseline characteristics showed no differences across II groups. Mean (range) follow-up, in years, was 5.02 (1.04-12.74) for all patients. Mean logMAR VA (Snellen VA) were 0.60 (20/80) and 0.56 (20/73) at baseline, 0.52 (20/66) and 0.59 (20/78) at Year 1, 0.45 (20/56) and 0.67 (20/94) at Year 2, 0.38 (20/48) and 0.66 (20/91) at Year 3, 0.41 (20/51) and 0.89 (20/155) at Year 4, and 0.35 (20/45) and 0.79 (20/123) at Year 5 for the high and low II groups, respectively. Linear regression analysis showed a gain of 0.5 approxETDRS letters with each additional injection per year.Conclusion:Increased II was associated with better mean VA, suggesting that long-term continuous vascular endothelial growth factor suppression may improve VA in eyes thought to carry poor prognoses.
KW - age-related macular degeneration
KW - injection index
KW - retinal pigment epithelial detachment
UR - http://www.scopus.com/inward/record.url?scp=85120560994&partnerID=8YFLogxK
U2 - 10.1097/IAE.0000000000003224
DO - 10.1097/IAE.0000000000003224
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C2 - 34673665
AN - SCOPUS:85120560994
SN - 0275-004X
VL - 41
SP - 2229
EP - 2235
JO - Retina
JF - Retina
IS - 11
ER -