Physiological functions of the ubiquitin ligases nedd4-1 and nedd4-2

Daniela Rotin, Gali Prag

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


The Nedd4 family of E3 ubiquitin ligases, consisting of a C2-WW(n)-HECT domain architecture, includes the closely related Nedd4/Nedd4-1 and Nedd4L/ Nedd4-2, which play critical roles in human physiology and pathophysiology. This review focuses on the regulation of enzymatic activity of these Nedd4 proteins, as well as on their roles in regulating stability and function of membrane and other signaling proteins, such as ion channels, ion transporters, and growth factor receptors. The diseases caused by impairment of such regulation are discussed, as well as opportunities and challenges for targeting these enzymes for therapy.

Original languageEnglish
Pages (from-to)18-29
Number of pages12
Issue number1
StatePublished - Jan 2024


FundersFunder number
Canadian Institute of Health Research FoundationFDN-159918
Cystic Fibrosis Canada555377
Israel Science Foundation1440/21
Israel Cancer Research Fund940283


    • E3 ubiquitin ligase
    • NEDD4L
    • Nedd4
    • Signaling
    • Ubiquitin


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