Physiological and pathological implications of laminins: From the gene to the protein

María Carolina Páez; María Julieta González; Norma C. Serrano; Yehuda Shoenfeld; Juan Manuel Anaya

doi:10.1080/08916930600911519

Physiological and pathological implications of laminins: From the gene to the protein

María Carolina Páez, María Julieta González, Norma C. Serrano, Yehuda Shoenfeld, Juan Manuel Anaya^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sjögren’s syndrome (SS) are also discussed.

Original language	English
Pages (from-to)	83-94
Number of pages	12
Journal	Autoimmunity
Volume	40
Issue number	2
DOIs	https://doi.org/10.1080/08916930600911519
State	Published - 2007

Funding

Funders	Funder number
Colombia and Fondecyt	1050192
Fundación para la Promoción de la Investigación y Tecnología
Universidad Autónoma de Bucara-manga

Keywords

Basal lamina
Extracellular matrix
Laminin
Sjögren’s syndrome
Systemic lupus erythematosus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/08916930600911519

Cite this

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abstract = "The extracellular matrix plays an important role in modulating the behavior of cells with which it interacts. There are a number of families of extracellular matrix (ECM) proteins including collagens, proteoglycans and laminins (LM). LM are the major component of the basal lamina (BL). Here, we review the current knowledge on their structure, self-assembly, binding mechanisms, diverse tissue-expression patterns and its impact on pathology. Studies and hypothesis exploring the role of LM and their polymorphic genes on autoimmune diseases (AIDs) such as systemic lupus erythematosus and Sj{\"o}gren{\textquoteright}s syndrome (SS) are also discussed.",

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AU - Shoenfeld, Yehuda

AU - Anaya, Juan Manuel

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KW - Extracellular matrix

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Physiological and pathological implications of laminins: From the gene to the protein

Abstract

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Keywords

UN SDGs

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