Physical vapor deposition of peptide nanostructures

Becky Bank-Srour, Peter Becker, Leonid Krasovitsky, Alexander Gladkikh, Yuri Rosenberg, Zahava Barkay, Gil Rosenman

Research output: Contribution to journalArticlepeer-review

Abstract

Biological units such as proteins and peptides have the intrinsic ability to self-assemble into natural biological nanostructures such as DNA strands, proteins and amyloid fibers. These assemblies have become an inspiration for development of new supramolecular nanostructural materials self-assembled from chemically synthesized peptides and proteins. Bioinspired materials are in the center of interest in research and development, as they are considered as a new generation of functional soft materials, which can be used in a variety of applications. Peptide nanostructure deposition technology is a key problem in the emerging field of bottom-up nanotechnology of these bioinspired nanomaterials. It has been mainly performed by solution deposition or by a vapor transport method. In this study, we describe a new technique of physical vapor deposition (PVD) of biomolecules compatible with microelectronic technology allowing fabrication of dense and homogeneous peptide nanostructural materials. We present a deep insight into the self-assembly mechanism of peptide nanostructures deposited by our developed PVD technique, a study of their elementary growth stages by investigation of fine morphological and packing structure, molecular composition, and their chemical and physical properties. These have enabled us to develop a controllable deposition technology for fabricating peptide nanostructures.

Original languageEnglish
Pages (from-to)494-503
Number of pages10
JournalPolymer Journal
Volume45
Issue number5
DOIs
StatePublished - May 2013

Keywords

  • diphenylalanine (FF)
  • peptide nano structures
  • physical vapor deposition (PVD)
  • self-assembly mechanism

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