Physical Localization of Microsatellite Markers at the Ataxia-Telangiectasia Locus at 11q22-q23

Lina Vanagaite, Kinneret Savitsky, Galit Rotman, Yael Ziv, Steven C. Gerken, Ray White, Jean Weissenbach, Godfrey Gillett, Frances J. Benham, Charles W. Richard, Michael R. James, Francis S. Collins, Yosef Shiloh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The autosomal recessive disorder ataxia-telangiectasia (A-T) is genetically heterogeneous, with four complementation groups. The genes for the two major groups (ATA and ATC) have been mapped to 11q22-q23. Genetic analysis of the disease has been conducted to date using biallelic polymorphisms. We have physically mapped to this region eight new microsatellite markers that were generated by three laboratories that construct whole-genome linkage maps. These markers should be valuable for refined localization and positional cloning of the A-T genes and for diagnostic purposes. The results demonstrate the value of integrating genetic and physical maps by different laboratories.

Original languageEnglish
Pages (from-to)231-233
Number of pages3
JournalGenomics
Volume22
Issue number1
DOIs
StatePublished - 1 Jul 1994

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