Photodynamic therapy of hypervascular cutaneous tissues in animal models using porphyrin or phthalocyanine activated by red light

J. Stuart Nelson*, Arie Orenstein, Lih Huei Liaw, Sol Kimel, Michael W. Berns

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations

Abstract

Continued improvement in the results of laser treatment of port-wine stain (PWS), with reduction in scarring, will depend on the ability to use lasers to induce selective injury of only the abnormal blood vessels in the dermis. Photodynamic therapy (PDT), using an exogenous photosensitizing drug specifically activated by a certain wavelength of light, may be used to destroy selectively certain targets in the biological systems. The current study demonstrates, in the chicken comb animal model, that PDT using porphyrins and phthalocyanines activated by red light could be used to treat hypervascular dermal tissues.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsStephen N. Joffe, Kazuhiko Atsumi
PublisherPubl by Int Soc for Optical Engineering
Pages154-163
Number of pages10
ISBN (Print)0819402419
StatePublished - 1990
Externally publishedYes
EventProceedings of Laser Surgery: Advanced Characterization Therapeutics, and Systems II - Los Angeles, CA, USA
Duration: 14 Jan 199019 Jan 1990

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume1200
ISSN (Print)0277-786X

Conference

ConferenceProceedings of Laser Surgery: Advanced Characterization Therapeutics, and Systems II
CityLos Angeles, CA, USA
Period14/01/9019/01/90

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