Photodynamic therapy for choroidal neovascularization in young adult patients

Rita Ehrlich, Michal Kramer, Irit Rosenblatt, Dov Weinberger, Karin Mimouni, Ethan Priel, Ruth Axer-Siegel

Research output: Contribution to journalArticlepeer-review

Abstract

We report our experience with photodynamic therapy (PDT) in the treatment of choroidal neovascularization (CNV) in young adult patients. This was a retrospective study of young adults with CNV treated with PDT. Data collected included age, diagnosis, type and size ofCNV, number of treatments, visual outcome, and side effects. Ten patients (11 eyes) were included in the study (mean age 27.2 plusmn; 13.3 years). Etiologies included multifocal choroiditis (3 eyes), idiopathic CNV (5 eyes), central serous chorioretinopathy (1 eye), and toxoplasma (2 eye). The mean number of treatments was 2 plusmn; 0.7 and the mean follow-up time was 13.1 plusmn; 9.5 months. Initial visual acuity (VA) ranged from 20/25 to 20/1,200 (mean logMAR 0.6 plusmn; 0.5), and improved to 20/20 to 20/250 (mean logMAR 0.46 plusmn; 0.4) (P = 0.51). Of the four eyes that received additional treatment with oral steroids, one of which also received intravitreal bevacizumab (Avastin) injections, all had visual acuity improvement of 2 or more lines, while only two of seven eyes that received PDT alone showed such improvement. PDT can improve visual outcome in a subgroup of young patients with subfoveal CNV especially when supplemented with oral steroid an bevacizumab injections.

Original languageEnglish
Pages (from-to)345-351
Number of pages7
JournalInternational Ophthalmology
Volume30
Issue number4
DOIs
StatePublished - Aug 2010

Keywords

  • Choroidal neovascularization
  • Photodynamic therapy
  • Young

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