Photodynamic inactivation of mold fungi spores by newly developed charged corroles

Annegret Preuß*, Irena Saltsman, Atif Mahammed, Michael Pfitzner, Israel Goldberg, Zeev Gross, Beate Röder

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The photodynamic effect, originally used in photodynamic therapy (PDT) for the treatment of different diseases, e.g. of cancer, has recently been introduced for the inactivation of bacteria. Mold fungi, which provoke health problems like allergies and diseases of the respiratory tract, are even more resistant and their biology is also very different. This study presents the development of four new photosensitizers, which, in combination with low doses of white light, inhibit the germination of mold fungi spores. Two of them even cause lethal damage to the conidia (spores) which are responsible for the spreading of mold fungi. The photoactivity of the newly synthesized corroles was obtained by their application on three different mold fungi: Aspergillus niger, Cladosporium cladosporoides, and Penicillium purpurgenum. To distinguish between inactivation of germination and permanent damage, the fungi were first incubated under illumination for examination of photosensitizer-induced growth inhibition and then left in darkness to test the survival of the conidia. None of the compounds displayed dark toxicity, but all of them attenuated or prevented germination when exposed to light, and the positively charged complexes induced a complete damage of the conidia.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalJournal of Photochemistry and Photobiology B: Biology
StatePublished - 5 Apr 2014


  • Aspergillus
  • Charged corroles
  • Cladosporium
  • Conidia
  • Mold fungi
  • Penicillium
  • Photodynamic effect
  • Phototoxicity
  • Singlet oxygen generation


Dive into the research topics of 'Photodynamic inactivation of mold fungi spores by newly developed charged corroles'. Together they form a unique fingerprint.

Cite this