TY - JOUR
T1 - Photochemotherapy of hypervascular dermal lesions
T2 - A possible alternative to photothermal therapy?
AU - Orenstein, Arie
AU - Nelson, J. Stuart
AU - Liaw, Lih‐Huei L.
AU - Kaplan, Ross
AU - Kimel, Sol
AU - Berns, Michael W.
PY - 1990
Y1 - 1990
N2 - Continued improvement in the results of laser treatment of port wine stain, with reduction in scarring, will depend on the ability to use lasers to induce selective injury of only the abnormal blood vessels in the dermis while sparing the normal overlying epidermis. Photodynamic therapy, using an exogenous photosensitizing drug specifically activated by certain wavelengths of light, may be used to destroy selectively certain targets in biological systems. The current study demonstrates, in the chicken comb model, that photochemotherapy can be used to treat hypervascular dermal lesions while leaving the normal overlying epidermis completely intact.
AB - Continued improvement in the results of laser treatment of port wine stain, with reduction in scarring, will depend on the ability to use lasers to induce selective injury of only the abnormal blood vessels in the dermis while sparing the normal overlying epidermis. Photodynamic therapy, using an exogenous photosensitizing drug specifically activated by certain wavelengths of light, may be used to destroy selectively certain targets in biological systems. The current study demonstrates, in the chicken comb model, that photochemotherapy can be used to treat hypervascular dermal lesions while leaving the normal overlying epidermis completely intact.
KW - chicken combs
KW - laser
KW - photodynamic therapy
KW - port wine stain
KW - vascular skin lesions
UR - http://www.scopus.com/inward/record.url?scp=0024987438&partnerID=8YFLogxK
U2 - 10.1002/lsm.1900100406
DO - 10.1002/lsm.1900100406
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AN - SCOPUS:0024987438
SN - 0196-8092
VL - 10
SP - 334
EP - 343
JO - Lasers in Surgery and Medicine
JF - Lasers in Surgery and Medicine
IS - 4
ER -